Frontline Plus vs Nexgard
Topical spot-on vs oral chewable. Which flea and tick treatment is right for your dog? We compare effectiveness, safety, convenience, and price.
Quick Comparison
| Factor | Frontline Plus | Nexgard |
|---|---|---|
| Type | Topical spot-on | Oral chewable |
| Active ingredient | Fipronil + (S)-methoprene | Afoxolaner |
| Kills fleas in | 12 hours | 4 hours |
| Kills ticks | Yes (48 hours) | Yes (24 hours) |
| Water exposure | Wait 48h after application | No restriction |
| Min age | 8 weeks | 8 weeks / 4 lbs |
| Best for | All breeds, budget-friendly | Dogs who swim/ hate topicals |
Our Verdict
Both are excellent products. Choose Frontline Plus if you want the most affordable option and your dog tolerates topical application. Choose Nexgard if your dog swims frequently, hates being handled, or you have young children who might touch the application site. For maximum savings, buy Frontline Plus from CanadaPetCare (12% off + free shipping). For Nexgard, use BestVetCare's Big Cart Sale ($5 off every item).
