K9 Advantix for Dogs

The only topical that repels AND kills fleas, ticks, mosquitoes, biting flies, and lice. Before they bite.

Do not use on cats. K9 Advantix contains permethrin, which is toxic to cats. If you have a dog and cat in the same household, keep them separated for 24 hours after application. A cat that grooms a recently treated dog can suffer tremors, seizures, and death.

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What Makes K9 Advantix Different

Most flea and tick products only kill parasites after they bite. K9 Advantix repels them before contact. This matters if you walk your dog in wooded or grassy areas where ticks carry disease. A tick that never attaches cannot transmit Lyme, ehrlichiosis, or anaplasmosis.

The formula combines imidacloprid (kills fleas), permethrin (repels and kills ticks, mosquitoes, flies), and pyriproxyfen (insect growth regulator that stops flea eggs from hatching). The repellent effect starts within minutes of application.

Dosage by Weight

Dog WeightPack SizeDuration
4 - 10 lbs4 or 6 doses4 or 6 months
11 - 20 lbs4 or 6 doses4 or 6 months
21 - 55 lbs4 or 6 doses4 or 6 months
Over 55 lbs4 or 6 doses4 or 6 months

Apply to the skin between the shoulder blades once monthly. Do not bathe for 48 hours after application.

Who Should Use It

K9 Advantix is best for:

Skip it if you have cats that groom your dog or share bedding. The risk is manageable โ€” 24 hours of separation after application โ€” but some owners decide the logistics are not worth it. In that case, Nexgard or Frontline Plus are safer alternatives for mixed-pet homes.

Side Effects

Skin reactions at the application site are the most common complaint: temporary redness, itching, or hair thinning where the liquid was applied. These usually resolve within a few days. A small number of dogs show restlessness or excessive grooming right after application โ€” this is usually a reaction to the sensation of the liquid, not the drug itself.

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